Hepatocellular Carcinoma
Conditions
Interventions
Sponsors
the First Affiliated Hospital,College of Medicine,Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Histologically or cytologically confirmed diagnosis of unresectable Hepatocellular Carcinoma; 2. BCLC Staging as C period; 3. Child-pugh liver function Rating: A level, B level (= score 7); 4. aged 18-80 years male and female; 5. ECOG (Eastern Cooperative Oncology Group) 0~2; 6. Normal hemodynamic indices before the recruitment (including blood cell count and liver/kidney function ). For example: HB=90 g/L, ANC>1.5×10^9/L; PLT>50×10^9/L, TBIL<1.5 times of upper limit of normal reference value, ALT and AST<2.5 times of upper limit of normal reference value(Liver metastasis:<5×ULN), and CR=1.25 ×ULN; 7. Signed the Informed Consent Form.
Exclusion criteria
Exclusion criteria: 1. patients with cholangiocarcinoma or combined hepatocellular-cholangiocarcinoma; 2. Those who have received previous treatments such as surgery or RFA; 3. BCLC stage D; 4. Child-Pugh C or worse B (> 7 points); 5. CT or MRI imaging findings suggest that there are obvious arteriovenous fistulas; 6. recently (= 3 months) have gastrointestinal bleeding (hematemesis or melena); 7. acccompanied with serious infections such as liver abscess; 8. acccompanied with other malignant tumors that are not effectively controlled; 9. acccompanied with HIV-infected patients; 10. The investigator judges other conditions that may affect the conduct of the clinical study and the outcome of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| OS;DCR;ORR; | — |
Countries
China
Contacts
Public ContactTan-yang Zhou
the First Affiliated Hospital,College of Medicine,Zhejiang University
Outcome results
None listed