primary nephrotic syndrome?Henoch-Schonlein purpura nephritis
Conditions
Interventions
Case series:NA
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. Diagnostic criteria for primary nephrotic syndrome: massive proteinuria: 24-hour proteinuria (> 50mg/kg) or morning urine protein/creatinine (> 2.0 mg/mg) (++-++++++); hypoalbuminemia: serum albumin (> 25g/L); hyperlipidemia: serum cholesterol (> 5.7mmol/L); edema of varying degrees. 1 and 2 of the above 4 items are necessary conditions for diagnosis; 2. Henoch-Schonlein purpura (HSP) was diagnosed according to EULAR and Pres criteria in 2006. Contact (essential) rash with any of the following: 1) diffuse abdominal pain; 2) obvious IgA deposition on biopsy; 3) acute arthritis or arthralgia in any joint; 4) kidney Visceral damage is manifested as hematuria or proteinuria. Henoch-Schonlein purpura nephritis (HSPN) was established by the nephrology group of Chinese Medical Association in 2009, HSPN classification criteria and treatment guidelines (evidence-based guidelines for the diagnosis and treatment of HSPN (trial). The diagnostic criteria for HSPN were: hematuria and (or) proteinuria within 6 months of the course of HSP. The diagnostic criteria of hematuria and albuminuria were: (1) hematuria: gross hematuria or microscopic hematuria, gross hematuria or microscopic hematuria three times a week. Red blood cells were more than 3 / high magnification (HP); (2) albuminuria: satisfy any of the following: 1) 3 times within a week urinary routine protein positive; 2 24 hours urinary protein quantitative > 150 mg; 3 times within a week urinary microalbumin higher than normal value. In addition, HSPN should also be diagnosed in patients with recurrence of purpura, first hematuria and/or proteinuria after 6 months of HSP; 3. Outpatient health check-up children: in the study period and place, the included healthy children had no history of major diseases (except occasional upper respiratory tract infection), family members had no history of inbreeding, no family history of disease (strict identification of family history of kidney disease), the children and their parents had no abnormalities.
Exclusion criteria
Exclusion criteria: Chronic kidney disease caused by factors other than primary nephrotic syndrome and allergic purpura (lupus, hepatitis B, diabetes, genetic nephritis) was excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WES;Treatment remission rate; | — |
Countries
China
Contacts
Public ContactQiu Li
Children's Hospital of Chongqing Medical University, Chongqing, People’s Republic of China
Outcome results
None listed