Sunject with chronic HBV infection
Conditions
Interventions
Gold Standard:Liver biopsy and pathological examination
1) the grading of liver injury was evaluated by modified Knodell score
2) the staging of fibrosis was evaluated by modified Metavir score.
Index test:serum 
Glt25D1 
(ELISA)
 
(FibroaScan)
Sponsors
Beijing Ditan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients with chroninc HBV infection; 2. Age 18-60 years old; 3. Clinical examination follow-up records showed continued normal liver function; 4. The history of HBV infection was more than 10 years; 5. Sign informed consent; 6. Consent to liver biopsy. 7. No severe organ dysfunction or failure; 8. Normal coagulation function.
Exclusion criteria
Exclusion criteria: 1. Contraindications for liver biopsy; 2. There are other hepatoviral infections or other chronic liver diseases, including non-alcoholic fatty liver disease, alcoholic and non-alcoholic hepatitis, drug-induced liver injury, and autoimmune liver diseases,et al.; 3. Chronic systemic disease with liver involvement; 4. Abnormal coagulation function; 5. There are other clinical conditions not suitable for liver puncture.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum Glt25D1;liver biopsy and pathological diagnosis; | — |
Countries
China
Contacts
Public ContactHongshan Wei
Beijing Ditan Hospital, Capital Medical University
Outcome results
None listed