post-stroke cognitive impairment
Conditions
Interventions
Group 1:cTBS
Group 2:sham-cTBS
Sponsors
Beijing Tiantan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. First stroke confirmed by computed tomography (CT) scan or magnetic resonance imaging (MRI), which occurred less than 12 months; 2. Evidence of stroke related cognitive impairment, documented by neuropsychological evaluation; 3. Aged 40-80 years; 4. Education: primary school (grade 6) or above; 5. Mini-Mental State Examination (MMSE) score of =15; Montreal Cognitive Assessment (MoCA) score less than 26; 6. The Hamilton depression rating scale (HAMD) score of <17; 7. Not on drugs for cognitive improvement; 8. Have a stable and reliable caregiver; 9. Written consent form signed by the patient.
Exclusion criteria
Exclusion criteria: 1. Bilateral or subtentorial lesions; 2. The history of nervous system diseases, including stroke, brain tumor, brain trauma, etc.; 3. Other causes of cognitive decline: AD, PD, FTD, DLB, VitB12 deficiency, hypothyroidism, etc.; 4. Severe alcoholism and drug abuse; 5. Taking medications that may negatively affect cognitive function, such as anticholinergics, antipsychotics and anticonvulsants; 6. Contraindication to MRI scanning; 7. Contraindication to TMS treatment; 8. Psychiatric patients, including schizophrenia, bipolar disorder, major depression or delirium; 9. Vision or hearing problems that lead to poor performance of cognitive tests; 10. Diagnosis of language deficits or aphasia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the Alzheimer’s Disease Assessment Scale, cognitive subscale, ADAS-cog; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment, MoCA;Mini-Mental State Examination, MMSE;Digit Span Test;Stroop Test;Trail Making Test;Category Fluency Test;Clock Drawing Test;Modified Barthel Index;Quality of Life; | — |
Countries
China
Contacts
Public ContactGuangqing Xu
Beijing Tiantan Hospital, Capital Medical University
Outcome results
None listed