Kawasaki Disease
Conditions
Interventions
Group 1:glucocorticoid combined with immunoglobulin
Group 2:immunoglobulin
Sponsors
Qingdao Women and Children's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 2017 AHA Kawasaki disease diagnostic standard: 1. Fever lasts for more than 5 days and is accompanied by at least 4 of the following 5 main characteristics: (1) Changes in limbs: In the acute phase, erythema and edema of the hands and feet, during the recovery period, membranous desquamation of the fingertips; (2) pleomorphic rash; (3) bilateral painless conjunctival hyperemia without exudate; (4) Lip and mouth changes: lip flushing and cleft palate, strawberry tongue, oral and pharyngeal mucosa diffuse Redness; (5) swelling of the cervical lymph nodes (diameter = 1.5cm), usually unilateral. 2. Fever with the above-mentioned main clinical manifestations of less than 4, if two-dimensional echocardiography or coronary angiography found coronary artery disease, can be diagnosed as Kawasaki disease; 3. Has only 2 or 3 main features, and excludes febrile diseases such as scarlet fever, drug allergy syndrome, Stevens-Johnson syndrome, toxic shock syndrome, adenovirus infection, EB virus infection, and juvenile rheumatoid arthritis Connective tissue diseases such as exudative erythema multiforme and systemic lupus erythematosus; 4. In the case of typical clinical manifestations, except for other febrile diseases and connective tissue diseases.
Exclusion criteria
Exclusion criteria: 1. Children with congenital diseases, such as children with diseases such as immunodeficiency and congenital heart disease; 2. Merged or secondary bacterial, tuberculosis, or viral infections; 3. Children with IVIG or adrenocortical hormone have not been standardized before admission. 4. KDSS or children with Kawasaki disease who combined MAS.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| drug resistance rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence of coronary arterial lesions;hospitalization expenses;the time for eliminating the clinical symptoms;The incidence of glucocorticoid side effects;NT-proBNP;blood pressure;alanine transaminase; | — |
Countries
China
Contacts
Public ContactZipu Li
Qingdao Women and Children's Hospital
Outcome results
None listed