Cancer
Conditions
Interventions
Case series:Intravenous injection of cisplatin-microparticles with synchronous local radiotherapy
Sponsors
5th Hospital of Wuhan
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Locally advanced non-small cell lung cancer is confirmed by pathology, including stage III can not or will not surgery and stage IV patients, progression of disease through conventional system chemotherapy; 2. Stable vital sign with Karnofsky index (KPS - Karnofsky Performance Status) more than 70; and the expected survival time is longer than 3 months. 3. age 18-75 years old; 4. Normal bone marrow hematopoietic function, no bleeding, blood routine: HGB=90g/L, WBC=4.0*10^9/L; (NEU=1.5*10^9/L), PLT=100*10^9/L; 5. Liver function: total bilirubin =1.5ULN; AST?ALT=2.5ULN; Alkaline phosphatase=1.5ULN; 6. BUN within 1.5 time upper limit of normal; Creatinine clearance rate = 50mL/min; 7. Normal ECG, normal blood sugar levels;without other severe comorbidities. 8. Agreed to participate in the study and sign an informed consent.
Exclusion criteria
Exclusion criteria: 1. Without pathological diagnosis; 2. Pregnant or lactating patients; 3. Allergy to multiple drugs; 4. With other severe comorbidities or psychological diseases; 5. Severe infection; 6. Cognitive dysfunction; 7. Participation in other clinical trials within the recent four weeks; 8. Not available to participate in this clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Safety evaluation;Objective remission rate (ORR);Disease control rate (DCR); | — |
Secondary
| Measure | Time frame |
|---|---|
| Tumor markers;Progression-Free Survival (PFS);Overall survival (OS); | — |
Countries
China
Contacts
Public ContactZhixiong Long
5th Hospital of Wuhan
Outcome results
None listed