Functional gastrointestinal diseases
Conditions
Interventions
Gold Standard:Clinical outcome:
1. Utilize high resolution esophageal manometry as referance standards for esophageal motiity disorders
2. Utilize electrogastrogram and gastric emptying test as referance standards for functional dispepsia and diabetic gastroparesis
3. Utilize anorectal manometry and colonic transit test as referance standards for
Index test:Microcapsule 
image 
and 
biodynamic 
Sponsors
Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. healthy subjects: (1) Ages among 18-65, healthy subjects; (2) Without any symptom of digestive tract such as acid regurgitation, heartburn, belching, nausea, vomiting, dysphagia, foreign body sensation of the pharynx, constipation, diarrhea, abdominal distention. 2. subjects with esophageal motility disorders: (1) Aged 18-65 years; (2) Conform to the Chicago Classification v3.0 by high resolution esophageal manometry. 3. subjects with functional dispepsia or chronic constipation: (1) Aged 18-65 years; (2) Conform to Rome III standards for functional GI diseases; 4. subjects with diabetic gastroparesis: (1) Aged 18-65 years; (2) with a history of chronic diabetics; (3) Conform to diagnostic standards for diabetic gastroparesis.
Exclusion criteria
Exclusion criteria: 1. healthy subjects (1) With any kinds of organic diseases; (2) Pregnant women, or with mental disorders. 2. subjects with esophageal motility disorders: (1) With any other kinds of serious organic diseases; (2) Pregnant women, or with mental disorders. 3. subjects with functional dispepsia or chronic constipation: (1) With any kinds of organic diseases; (2) Pregnant women, or with mental disorders. 4. subjects with diabetic gastroparesis: (1) With any other kinds of serious organic diseases; (2) Pregnant women, or with mental disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Transit time of different segments of gastrointestinal tract in healthy individuals and patients with functional gastrointestinal diseases;Maximal speed of the capsule movement in different segments of GI tract in healthy subjects and patients with FGIDs;Mean speed of the capsuel movement in different segments of GI tract in healthy subjects and patients with FGIDs;Mean single forward movement length of the capsule in different segments of GI tract in healthy individuals and patients with FGIDs;Number of the backward and forward movement of the capsule in different segments of the GI tract in healthy subjects and patients with FGIDs;Maximal pressure of different segments of the GI tract in healthy subjects and patients with FGIDs;Minimal pressure of different segments of the GI tract in healthy subjects and patients with FGIDs;Mean pressure of different segments of the GI tract in healthy individuals and patients with FGIDs;Tolerance and adverse effect; | — |
Secondary
| Measure | Time frame |
|---|---|
| Endoscope image of different segments of GI tract in healthy individuals and FGIDs; | — |
Countries
China
Contacts
Public ContactLiu Jun
Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed