Skip to content

Factors predicting responses to Berberine Hydrochloride in the prevention of colorectal adenomas recurrence and its effect on the intestinal microflora

Factors predicting responses to Berberine Hydrochloride in the prevention of colorectal adenomas recurrence and its effect on the intestinal microflora

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1800017965
Enrollment
Unknown
Registered
2018-08-25
Start date
2018-10-30
Completion date
Unknown
Last updated
2018-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal adenoma

Interventions

A:BBR 0.3 bid oral
B:placebo 0.3 bid oral

Sponsors

Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Individuals aged 18-75 years; 2. Individuals who had histologically confirmed CRAs removed by endoscopy (EMR\ESD\APC) within 1 months before recruitment; 3. Individuals who had excluded the family history of familial colorectal adenoma or polyposis; 4. Individuals who voluntarily sign the consent form after being fully informed and understanding the purpose and procedure of this study, characters of the disease, effect of medication, methods of related examinations, and potential risk/benefits of the study.

Exclusion criteria

Exclusion criteria: 1. Individuals with any cancer or cancer history; 2. Individuals with severe disease and the expected survival time is no more than 3 years; 3. Individuals who are intolerant to another colonoscopy examination; 4. Pregnant women, women during breast-feeding period, or women with expect pregnancy; 5. Individuals with mental diseases who are not able to cooperate; 6. Individuals with allergic constitution, known to be allergic to BBR; 7. Any unsuitable condition considered by the researchers.

Design outcomes

Primary

MeasureTime frame
The recurrence rate of CRA;

Secondary

MeasureTime frame
incidence rates of all polypoid lesions;fecal microflora;

Countries

China

Contacts

Public ContactYingxuan Chen

Renji Hospital, School of Medicine, Shanghai Jiao Tong University

yingxuanchen71@sjtu.edu.cn+86 13916009239

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026