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Proton pump inhibitor (esomeprazole /omeprazole /pantoprazole) Combined with Megestrol for Preventing Highly Emetogenic Chemotherapy Induced Nausea and Vomiting

Proton pump inhibitor (esomeprazole /omeprazole /pantoprazole) Combined with Megestrol for Preventing Highly Emetogenic Chemotherapy Induced Nausea and Vomiting

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1800017953
Enrollment
Unknown
Registered
2018-08-24
Start date
2018-08-25
Completion date
Unknown
Last updated
2018-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tumor

Interventions

Group 1:four-way antiemetic regimen

Sponsors

Henan Cancer Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Tumor patients diagnosed by histopathology or cytology, as long as the chemotherapy with cisplatin is used, the amount of cisplatin is 60-80 mg/m2; 2. Unlimited gender, age 18 to 70 years old; 3. ECOG physical status score 0-1; 4. The survival time is predicted to be more than 3 months; 5. Bone marrow hematopoietic function was not significantly impaired (WBC=3.5109/L, ANC=1.5109/L, PLT=100109/L, Hb=100g/L); 6. Biochemical examination AST / ALT = 2.5 times the upper limit of normal; bilirubin = 1.5 times the upper limit of normal; creatinine clearance = 60ml / min, normal ECG; 7. Signing informed consent;

Exclusion criteria

Exclusion criteria: 1. Women who are pregnant or breastfeeding, women of childbearing age who refuse to receive contraception; 2. Brain metastasis; 3. Combine all of the following serious or uncontrolled diseases that affect participation in the trial: (1) Uncontrollable hypertension, history of unstable hypertension, or poor adherence to antihypertention drugs; (2) Unstable angina; (3) Symptomatic congestive heart failure; (4) Myocardial infarction occurred within 6 months before enrollment; (5) Severe uncontrollable arrhythmia; (6) Uncontrollable diabetes; (7) Active or uncontrollable infection; (8) Intestinal paralysis, intestinal obstruction, interstitial pneumonia, active gastric ulcer; (9) Subject to immunosuppressive therapy; 4. Inability to understand or express informed consent; 5. The investigator judged other conditions that were not suitable for clinical research.

Design outcomes

Primary

MeasureTime frame
Vomiting control rate;

Countries

China

Contacts

Public ContactLi Ning

Henan Cancer Hospital

lining@126.com+86 13526501903

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 21, 2026