Effect of Luteal estrogen pre-treatment in sub-optimal responders in GnRH antagonist protocol: a prospective randomized trial

Effect of Luteal estrogen pre-treatment in sub-optimal responders in GnRH antagonist protocol

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1800017931

Enrollment

Unknown

Registered

2018-08-22

Start date

2018-09-01

Completion date

Unknown

Last updated

2018-09-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility

Interventions

study group: Luteal estrogen pre-treatment

control group:no pre-treatment

Eligibility

Sex/Gender

Female

Age

20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Patients undergo IVF / ICSI-ET in our hospital's reproductive center: 1. age = 45 years; 2. AFC 4-9, AMH = 2.5 ng / ml; 3. BMI18-24; 4. previous IVF / ICSI cycles =3, and there was no remaining embryo.

Exclusion criteria

Exclusion criteria: 1. no hormone therapy during the past 6 weeks; 2. Severe systemic diseases such as severe impairment of liver and kidney function; 3. severe uterine malformations, endometriosis, adenomyosis and intrauterine adhesions; 4. PGD or PGS cycles; 5. patients with recurrent miscarriage and repeated implantation failure.

Design outcomes

Primary

Measure	Time frame
Cumulative live birth rate;	—

Secondary

Measure	Time frame
No. of oocytes retrieved;No. of available embryos;Abortion rate;	—

Countries

China

Contacts

Public ContactHu Xiuyu

Shenzhen Zhongshan Urology Hospital

jxsrhxy@163.com=86 13058140677

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026