cerebral small vessel disease
Conditions
Interventions
Case series:no
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Outpatients and inpatients; 2) Aged 50-80 years old; 3) MRI mainly showing mild to severe white matter damage(Fazekas grades 2,3) , accompanied with lacunar infarcts, cerebral microbleed, enlarged perivascular space. The diagnosis standards by neuroimaging are in accordance with Prevention of Stroke in Patients With Silent Cerebrovascular Disease- A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association; 4) The chief complaint of patients is cognitive impairment, possibly accompanied with affective disorders / sleep disorders/ gait disorder/urinary dysfunction/dysphagia; 5) Objective cognitive assessment showing at least one cognitive domain impairment.
Exclusion criteria
Exclusion criteria: 1) Cortical or large subcortical infarction (>2cm); 2) Intracranial or extracranial macrovascular (>50% stenosis); 3) White matter damage caused by other diseases , including MS/ toxication/ metabolic diseases; 4) Stroke not caused by cerebral small vessel disease; 5) Acute lacunar stroke onset within 3 months; 6) Other clinical manifestations not caused by cerebral small vessel disease, including Parkinson diseases; 7) Cognitive impairments and gait disorders caused by other diseases, including AD/ macrovascular cognitive impairment/ hydrocephalus; 8) Dementia; 9) Severe depression or communicative disorders; 10) Patients unable to sign consent forms and patients with poor compliance; 11) Patients with contraindications for MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| dementia;cerebral infarction events with area larger than 20mm;death; | — |
Secondary
| Measure | Time frame |
|---|---|
| The score of each scale changes more than one deviation compared with baseline;TIA?minor stroke; | — |
Countries
China
Contacts
Public ContactJianhui Fu
Department of Neurology, Huashan Hospital, Fudan University
Outcome results
None listed