Small Cell Lung Cancer
Conditions
Interventions
AIL Experimental:Intravenous return of AIL cells.There are 6 courses of treatment, 2 weeks between each course.The number of cells returned per treatment course: 1.2~1.5 X 10^8 cell/kg
NK Experimental:Intravenous return of NK cells.There are 6 courses of treatment, 2 weeks between each course.The number of cells returned per treatment course: 1.2~1.5 X 10^8 cell/kg
Control:No cell treatment
Sponsors
Shandong Provincial Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Clinically diagnosed as a small-cell lung cancer limitation period, including exact pathological diagnosis (cell morphology and immunohistochemistry to support small cell lung cancer diagnosis), imaging examination and serological examination (increased NSE with or without CA125 elevation, low Sodiumemia) supports the limited diagnosis of small cell lung cancer; 2) normal or normal blood picture (WBC=4×10^9/L), absolute value of peripheral blood lymphocytes=0.9×10^9/L; 3) After receiving the end of radiotherapy/chemotherapy, the clinical efficacy reached complete remission (CR). Received the experiment within 1 month after the end of radio/chemotherapy; 4) No serious virus or bacterial infection; blood donors have no blood-related diseases, no acute or chronic infectious diseases, and need to do hepatitis B virus, hepatitis C virus, HIV, syphilis Detection of pathogens such as spirochetes, which can be used as cell source donors after passing the test; 5) Non-pregnant and lactating patients; 6) No history of allergic reactions to immune products.
Exclusion criteria
Exclusion criteria: 1) Previously treated with AIL and NK cells; 2) Infected with uncontrolled activity; 3) History of severe heart disease, uncontrolled hypertension, unstable angina, or congestive heart failure; 4) Pregnancy or breastfeeding Women; 5) history of immune diseases associated with T lymphocytes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall Survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Disease Free Survival;Tumor progression to death survival;Patient's quality of life; | — |
Countries
China
Contacts
Public ContactWei Song
Shandong Provincial Hospital
Outcome results
None listed