depression disorder
Conditions
Interventions
ketamine group:single-dose i.v. ketamine (0.5mg/kg, 40 minutes)+ venlafaxine (4 weeks, 75mg/day in the first week and 150mg/day in the other 3 weeks)
control group:single-dose i.v. midazolam (0.045mg/kg, 40 minutes)+ venlafaxine (4 weeks, 75mg/day in the first week and 150mg/day in the other 3 weeks)
Sponsors
Beijing Chaoyang Hospital
Eligibility
Sex/Gender
All
Age
25 Years to 64 Years
Inclusion criteria
Inclusion criteria: (1) Diagnosis of non-psychotic major depression established by treating psychiatrists and confirmed by a checklist based on DSM-IV criteria at study entry; (2) Consistent with the criteria of treatment-resistant depression based on "Guidelines for the prevention and treatment of depression disorder in China (the second edition)"; (3) Total score of the 17-item Hamilton Rating Scale for Depression (HAMD)–Chinese version =17; (4) Male and female aged 25-64 years; (5) No antidepressants, antipsychotics, mood stabilizers, ECT and so on within two weeks; (6) Ability to understand the content of the scales and cooperate with assessment; (7) Ability to communicate and provide written consent.
Exclusion criteria
Exclusion criteria: (1) Lifetime history of drug/alcohol dependence, psychotic, bipolar or obsessive-compulsive disorders; (2) Any Axis I disorder other than major depression judged to be the primary presenting problem; (3) History of inefficacy or intolerance to venlafaxine hydrochloride; (4) Pregnant or breast-feeding; (5) Suicide attempt in the current episode; (6) Major medical conditions contraindicating the use of ketamine or midazolam or venlafaxine; (7) ECT or NMDA antagonist medications administered within the past 6 months; (8) Respiratory diseases, hypertension, or other serious physical diseases in the current episode.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montgomery-Asberg depression rating scale;16-item Quick Inventory of Depressive Symptomatology Self-Report; | — |
Countries
China
Contacts
Public ContactYongdong Hu
Beijing Chaoyang Hospital
Outcome results
None listed