Acute respiratory failure ,due to acute cardiogenic pulmonary edema, acute exacerbation of chronic obstructive pulmonary disease, chest trauma
Conditions
Interventions
Group 1:Noninvasive ventilation of helmet
Group 2:Noninvasive ventilation of mask
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of patient's disease complies with AECOPD, uniform diagnostic criteria for ACPE; (eg AECOPD patients diagnosed according to the guidelines of the global guidelines for prevention and treatment of COPD; heart underlying disease in ACPF patients, respiratory failure caused by ACPE) or patients with a history of trauma and Acute respiratory failure due to trauma or dyspnea requiring assisted ventilation; (eg pulmonary contusion, rib fractures, flail chest or sternal fracture, etc); 2. There is a need for assisted ventilation indicators: (1) moderate to severe dyspnea, manifested as shortness of breath (respiratory rate> 30 beats / min); or use of auxiliary breathing muscles or contracting chest and abdomen; or Pa02 45 mm Hg), or oxygenation index 10L/min) for at least 15min; 3. mediastinal or pericardial no active bleeding, pleural effusion drainage = 100mL/h; 4.Cyclic stability, no high-dose vasoactive drugs (epinephrine <0.05µg/kg/min, dopamine <5µg/kg/min), no serious arrhythmia; 5. urine output = 0.5 mL/kg/h, hemoglobin = 90g/L; 6. Exclusion of contraindications for the use of NIV.
Exclusion criteria
Exclusion criteria: 1. The presence of invasive mechanical ventilation indications, tracheal intubation and invasive ventilator assisted breathing as soon as possible; 2. Deterioration or disturbance of consciousness; 3. Hemodynamic instability (systolic blood pressure <90 mmHg, mean arterial pressure <50 mmHg, electrocardiogram suggestive of myocardial ischemia or severe arrhythmia); 4. Severe cardiac insufficiency (ejection fraction <25%) or cardiopulmonary obstruction; 5. Inhalation of high-risk, oropharyngeal and upper respiratory secretions can not be cleared, respiratory secretions or thick viscous sputum and sputum; 6. A history of malignancy or expected death within a short period of time due to the severity of the underlying disease; 7. Other organ dysfunction (gastrointestinal perforation / hemorrhage or severe cerebrovascular disease); 8. neck or face trauma, burns or upper airway bleeding or obstruction; 9. a large number of pleural effusion who did not drain; 10. Refuse to cooperate or refuse to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arterial oxygen partial pressure;Arterial carbon dioxide partial pressure;PH value;heart rate;respiratory rate;Arterial blood pressure;Tolerance scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intensive care unit hospital stay;Non-invasive ventilation time;Hospital mortality;Tracheal intubation rate;Complication rate; | — |
Countries
China
Contacts
Public ContactQiliu
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed