postoperative pain and postoperative cognitive dysfunction
Conditions
Interventions
intervention group:Oxycodone applied for postoperative PCA
Sponsors
Jianhui Gan
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age = 65 years old; 2. normal communication and expression ability; 3. those who intend to undergo total hip arthroplasty; 4. those who agree to use postoperative analgesia pump; 5. those who sign informed consent.
Exclusion criteria
Exclusion criteria: 1. participants without sufficient cognitive function and language skills or with abnormal MMSE scores before surgery or had a history of POCD or mental illness; 2. participants insensitive or hypersensitive to pain sensation; 3. participants with major organ system disease, uncontrolled hypertension diabetes, coronary heart disease; 4. participants with hypersensitivity to the study medications; 5. participants with analgesic drug is being used or had a history of drug abuse; 6. participants enrolled in other clinical trials were also excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of POCD;postoperative MMSE scores;postoperative VAS scores;postoperative serum levels of NSE; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative serum levels of Aß protein;incidence of postoperative side effects;consumption of PCIA pump; | — |
Countries
China
Contacts
Public ContactJianhui GAN
Tangshan People's Hospital,North China University of Science and Technology
Outcome results
None listed