Alzheimer's disease
Conditions
Interventions
Vascular risk factors intensive intervention group:Drug and health education
Multimodal intervention group:Multimodal intervetion including lifestyle andnutritional guidelines, daily physical exercise, vascular risk factor management, social and intellectual activity
control group:Regular healthcare
Sponsors
Shandong Provincial Hospital Affiliated to Shandong University
Eligibility
Sex/Gender
All
Age
60 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. Aged 60-79 years at the time of baseline investigation; 2. People has been living in Yanlou town, Yanggu county of Shandong province for more than one year.
Exclusion criteria
Exclusion criteria: 1. Patients with dementia or disability; 2. People with major depression or schizophrenia; 3. Severe disease such as malignant tumour; 4. Unable to complete the cognitive examination due to severe hearing, vision and/or language impairment; 5. Diseases limiting engagement in the intervention programs, especially physical activity/exercise (e.g.,hepatic dysfunction, renal dysfunction/failure, Parkinsons disease, paralysis, symptomatic cardiovascular and cerebrovascular diseases, and those who are unable to participate in intervention activities assessed by professional physicians); 5. Refuse to sign the inform consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Z-score of cognitive assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| physical activity;Incidence of MCI and dementia;Incidence of cardiovascular events;Survival rate;Control of primary vascular risk factors such as hypertension, diabetes and dyslipidemia; | — |
Countries
China
Contacts
Public ContactYifeng Du
Shandong Provincial Hospital Affiliated to Shandong University
Outcome results
None listed