Hypertension
Conditions
Interventions
Trail team:Hypertension medicion+Cryo-RDN intervention
Control team:Hypertension medicion+Renal
Sponsors
Zhongshan Hospital Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 80 years male or female; 2. Individual has the history of taking antihypertensive medicine =3 months; after at least 28 days(at least two types) of antihypertensive medicine according to the protocal, the office systolic blood pressue=140 mmHg and the office distolic blood pressure =90 mmHg; then the 24-hour Ambulatory Blood Pressure Monitoring (ABPM) average SBP =135 mmHg; 3. Individual does agree to cooperate with the research process and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Individual has secondary hypertension; 2. Individual has the history of renal intervention therapy(such as stents); 3.Individual has renal artery disease or morphological variation, including: aneurysm, stenosis, severe renal artery calcification, dissection, multiple renal artery, etc.; 4. Individual has experienced a myocardial infarction, unstable angina pectoris, syncope, or a cerebrovascular accident, or has widespread atherosclerosiswith documented intravascular thrombosis within 6 months of the screening period; 5. Individual has cardiac valvular disease with significant hemodynamic changes; 6. Individual has uncontrolled pulmonary hypertension; 7. Individual has eGFR of 1.5); 9. Individual has ICD history; 10. Individual has acute or severe systemic infections; 11. Individual has type 1 diabetes mellitus; 12. Individual has require long-term oxygen intake or mechanical ventilation other than nocturnal sleep apnea; 13. Individual has contrast sensitivity; 14. Individual has pregnant, lactating, and preparing for pregnancy; 15.Individual has alcohol and other drug addicts, mental patients; 16. Individual has disease which may adversely affect the safety of the subject or clinical study; 17. Individual has participated in clinical studies of other drugs or instruments; 18. The researchers considered it inappropriate to participate in this clinical study of patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour ambulatory systolic blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| 24-hour ambulatory diastolic blood pressure;24-hour mean blood pressure;Office systolic blood pressure;The change of medicine types;The change of medicine dose;Quantifying medication compliance;Evaluation of instrument performance;Major adverse events occur; | — |
Countries
China
Contacts
Public ContactJunbo Ge
Zhongshan Hospital Fudan University
Outcome results
None listed