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LncRNA: diagnostic markers for postoperative cognitive dysfunction and its mechanism in pathogenesis of postoperative cognitive dysfunction

LncRNA: diagnostic markers for postoperative cognitive dysfunction and its mechanism in pathogenesis of postoperative cognitive dysfunction

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800017674
Enrollment
Unknown
Registered
2018-08-08
Start date
2019-01-01
Completion date
Unknown
Last updated
2018-08-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative cognitive dysfunction diseases

Interventions

Case series:N/A

Sponsors

Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
60 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1) Aged at least 60 to 85 years old; 2) American Society of Anesthesiologists (ASA) grade I-III; 3) the consentshave been obtained from the patients and family members; 4) patients who underwent hip or knee replacement surgery.

Exclusion criteria

Exclusion criteria: 1) pre-operative MMSE<24; 2) patients who has nervous system diseases, preoperative stoke and other central nerve system diseases; 3) patients who has severe mental illness or long-term use of active substances; 4) patients who suffered multiple injury and craniocerebral injury.

Design outcomes

Primary

MeasureTime frame
WAIS-RC;WMS;lncRNA expression level;—

Secondary

MeasureTime frame
Intraoperative blood loss;Intraoperative urine output;Operation time;age;Education;—

Countries

China

Contacts

Public ContactZhang Ying

Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University

zhangying021210@163.com+86 13551720908

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026