hepatocellular carcinoma
Conditions
Interventions
Group 1:Neoadjuvant radiotherapy before operation
Group 2:Non intervention before operation
Sponsors
The Affiliated Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Female or male aged 18 years and over, but no more than 70 years; 2. Histologic or cytologic confirmation of advanced hepatocellular carcinoma; 3. CT imaging findings with microvascular invasion; 4. Single lesion,4cm<diameter=6cm; 5. ECOG=0-2, Child-pugh A-B; 6. Liver reserve function ICGR15<20%; 7. Patients had not received systemic venous chemotherapy ever before; 8. Be able to receive surgery; 9. Provision of informed consent; 10. Be able to follow the research program and follow up process.
Exclusion criteria
Exclusion criteria: 1. radiotherapy and chemotherapy with experimental drug within 3 months before the start of study therapy; 2. Have at least another primary malignant tumor; 3. Active infection with bacterial or fungal infection; 4. Patients with HIV infection, HCV infection, serious coronary artery disease or asthma, serious cerebrovascular disease or other diseases that the researchers think can not be entered into the group; 5. Women who are pregnant or breast feeding; 6. Drug abuse, clinical or psychological or social factors which will influence the informed. consent or the study implementation; 7. History of hepatectomy 8. influence the safety or compliance of the patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OS;PFS;Safety;Local recurrence;Intrahepatic metastases; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tumor marker;Routine blood test;liver function; | — |
Countries
China
Contacts
Public ContactXu Qingxiang
The Affiliated Hospital of Nanjing University Medical School
Outcome results
None listed