sepsis
Conditions
Interventions
Vit C group:continuos intravenous injection of Vitamin C with 200 mg/kg/h for 4 days
NS group:continuos intravenous injection of normal saline using the same dose as Vit C for 4 days
Sponsors
Department of emergency, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 year; 2. Meeting the diagnostic criteria for sepsis; 3. Onset within 72 hours; 4. avoiding to be pregnant in the whole period; 5. Signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. In the processing of treatment of tumor; 2. refusal of organ support therapy such as renal replacement therapy, vasoactive agents and mechanical ventilation; 3. in the period of pregnant or lactation; 4. with chronic ardiovascular, hepatic, respiratory or renal dysfunction before admission; chronic cardiovascular dysfunction requiring home mechanical hemodynamic support (e.g., ventricular assist device) or home chemical hemodynamic support (e.g., milrinone); chronic hepatic dysfunction requiring child-pugh C; chronic respiratory dysfunction requiring supplemental noninvasive oxygen via nasal cannula or NIPPV; chronic kidney disease requiring eGFR 150umol/L; 5. known kidney stone; 6. known allergy to vitamin C; 7. involved in other clinical trial; 8. use of immunosuppressants or glucocorticoids for more than two weeks (equivalent to 0.5 mg/kg prednisone or prednisolone), especially for autoimmune diseases or organ transplantation; 9. body weight>100kg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28 days mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| indication for organ function(liver,kidney,heart,lung,coagulation);sequential organ failure assessment (SOFA) score;VitC related adverse event (urine crystal, urine volume per day,indicatiors for kidney function);period for ventilation;period for renal replacement therapy;period for vasoactive agents application;plasma level of VitaminC; | — |
Countries
China
Contacts
Public ContactMao Enqiang
Department of emergency, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed