Depression
Conditions
Interventions
Group 1:oral administration of Venlafaxine (75-225 mg/day)
Group 2:oral administration of Escitalopram (10-20 mg/day)
Sponsors
Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Male or female patients, 18-65 years of age; (2) Depression that meet the DSM-5 diagnostic criteria, including unipolar and bipolar depression; (3) Score of Hamilton Depression Scale > 17 when participants join in this study initially; (4) Participants must have an education equivalent to middle school or above; (5) Each participant must join in the study voluntarily and sign an informed consent.
Exclusion criteria
Exclusion criteria: (1) Other major psychiatric disorders that meet the DSM-5 diagnostic criteria include organic mental disorders, alcohol dependence, drug dependence/abuse, schizophrenia, etc; (2) Currently, there are serious and unstable somatic diseases such as diabetes, thyroid disease, hypertension, heart disease and narrow-angle glaucoma, etc; (3) A history of neurological diseases such as epilepsy and dementia; (4) Negative result on urotoxicological screening; (5) Women who are at the stage of pre-pregnancy, pregnancy or lataction; (6) Disobedient patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive Function; | — |
Countries
China
Contacts
Public ContactLi Mingding
Zhejiang University
Outcome results
None listed