colorectal cancer
Conditions
Interventions
treatment group:modified Scutellaria decoction+5-FU+irinotecan
Control group:5-FU+irinotecan
Sponsors
Eighth People's Hospital of Shanghai
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. there are definite histopathological diagnosis and imaging diagnosis; 2. all patients had an evaluable focus; 3. patients who were willing to be treated with chemotherapy and traditional Chinese medicine; 4. aged 18-75 years old, and the sex is not limited; 5. score of ECOG PS 0-2 points; patients who can eat; 6. all cases are expected to survive for more than 3 months; 7. TCM syndrome differentiation belongs to damp heat syndrom pattern.
Exclusion criteria
Exclusion criteria: 1. Lack of imaging or histopathological diagnosis, and the pathological or clinical stages were not clear; 2. Lack of definite lesion or no evaluation of lesions according to RECIST criteria; 3. patients who receive molecular targeted therapy (such as cetuximab, bevacizumab) and palliative surgery in the study phase; 4. women in pregnancy or lactation; 5. patients with severe cardiovascular, cerebrovascular and hematopoietic systems, serious impairment of liver and kidney function, patients with other severe complications, and psychosis patients; 6. patients with fasting or incapable of eating; 7. patients who are expected to live within 3 months of life; 8. patients with ECOG PS>2 score of physical state; 9. all cases that did not conform to the criteria for the entry of the group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of life score;Physical status assessment;Assessment of symptom improvement;Objective remission rate;Disease control rate;Index of toxicity;Safety index;Progression free survival time; | — |
Countries
Chian
Contacts
Public ContactZhang Suqin, Lian Peng
Shanghai Eighth People's Hospital
Outcome results
None listed