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Effects of genetic polymorphisms on clopidogrel and aspirin: a case-control study based on SPCM (Sequential Platelet Counting Method)

Effects of genetic polymorphisms on clopidogrel and aspirin: a case-control study based on SPCM (Sequential Platelet Counting Method)

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800017605
Enrollment
Unknown
Registered
2018-08-06
Start date
2018-08-10
Completion date
Unknown
Last updated
2018-08-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thrombotic diseases

Interventions

Sponsors

Henan Provincial People's Hospital, Zhengzhou University People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: (1) Male and female aged =18 years; (2) Using aspirin and clopidogrel for more than 3 days; (3) Chinese Han population; (4) The patients or their families agreed to voluntarily participated in this study, and signed informed consent.

Exclusion criteria

Exclusion criteria: (1) patients with severe liver and renal insufficiency; (2) patients with severe digestive ulcer; (3) patients with malignant tumors; (4) patients with allergy or intolerance to aspirin or clopidogrel; (5) patients received anticoagulant antiplatelet or thrombolytic therapy in one months; (6) poor compliance, unable to cooperate with the treatment; (7) patients with severe abnormal platelet function.

Design outcomes

Primary

MeasureTime frame
Maximum aggregation rate of platelets (MAR);Related genotype;

Secondary

MeasureTime frame
Number of primitive platelets;Mean volume of primitive platelets;Average aggregation rate of platelets;The maximum platelet aggregation time;

Countries

China

Contacts

Public ContactNingmin Zhao

Henan Provincial People's Hospital, Zhengzhou University People's Hospital

znm188@188.com+86 13513807401

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026