liver failure
Conditions
Interventions
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients with HBV-ACLF who received DPMAS plus PE therapy were enrolled. The diagnosis of HBV-ACLF was mainly based on the following criteria: (1) preexisting chronic HBV infection; (2) progressive hyperbilirubinemia, defined as a >50% increase in bilirubin or up to a level of >171µmol/L within 4 weeks; (3) international normalized ratio=1.5; (4) Patients aged 18 to 70 years.
Exclusion criteria
Exclusion criteria: Patients were excluded if they had drug-induced liver injury, immune liver disease, alcoholic liver disease, or hyperthyroidism or if they were pregnant. In this study, patients with HBV-ACLF were excluded if they were complicated with other viral infection (including hepatitis A, C, D, or E virus; cytomegalovirus; herpes simplex virus; or human immunodeficiency virus) or had evidence of chronic heart, pulmonary, or kidney disease. Exist of following conditions: History of malignant tumors or suspected malignant tumors; Planing to receive organ transplants or having undergone organ transplantation; Having suffered from cerebrovascular accidents, acute myocardial infarction and other major traumas within half a year; Recent history of surgery; Mental disorders or not cooperating. With active bleeding. With heparin and protamine allergy history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| coagulation rate;Completion rates of therapy;bleeding rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| APTT of extracorporeal circulation;APTT; | — |
Countries
China
Contacts
Public ContactLang Bai
West China Hospital, Sichuan University
Outcome results
None listed