Bacterial infection
Conditions
Interventions
Group A:Real-time therapeutic drug monitoring and measurement adjustment based on monitoring results
Group B:standard-of-care
Sponsors
Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. Patient aged less than 18 years old; 2. The patient is diagnosed with bacterial infection and must be treated with imipenem/cliastatin or meropenem; 3. No less than 3 days of hospitalization and no less than 5 times of treatment with imipenem/cilastatin or meropenem.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to imipenem/Sistine or meropenem; 2. The patients whose condition is extremely critical, and it is not suitable for them to participate in this study; 3. Patients who do not agree to the study or withdraw from the study due to personal reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma drug concentration of imipenem;Plasma drug concentration of meropenem; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical effects of imipenem/cilastatin;Clinical effects of meropenem;Microbiology analysis;Laboratory indexes of liver function;Safety evaluation; | — |
Countries
China
Contacts
Public ContactTao Yin
Department of Pharmacy, Xiangya Hospital, Central South University
Outcome results
None listed