Adolescent Idiopathic Scoliosis
Conditions
Interventions
A:2g intravenous TXA intraoperatively, and 0.5g intravenous TXA 6h 12h 18h postoperatively
B:2g intravenous TXA intraoperatively, and 1g oral TXA 4h, 10h, and 16h postoperatively
C:2g intravenous TXA intraoperatively
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
8 Years to 22 Years
Inclusion criteria
Inclusion criteria: 1. Patients following PSF due to AIS; 2. Patients with preoperative platelet and coagulation function dysfunction; 3. Voluntarily participated in clinical trials and signed informed consent, good compliance of patients.
Exclusion criteria
Exclusion criteria: 1. Patients with history of venous thromboembolism, pulmonary embolism, cerebral infarction, coronary heart disease; 2. Patients with coagulation disorders; 3. Anticoagulant drugs are being used; 4. Administration of NSAID for less than 1 weeks; 5. TXA allergy; 6. Severe liver and renal insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total blood loss;Hidden blood loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hb level;Hct;Hb drop;Hct drop;Intraoperative blood loss;Wound complications;Other adverse events;D-Dimer;Fibrin degradation products;Postoperative hospital stay ;Allogeneic blood transfusion rate; | — |
Countries
China
Contacts
Public ContactYueming Song
West China Hospital, Sichuan University
Outcome results
None listed