Myasthenia Gravis
Conditions
Interventions
Experiment group versus Control group:Thymectomy plus oral prednisone, an immunosuppressant protocol versus Prednisone, or immunosuppressants alone
Sponsors
The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
1 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria will include: Myasthenia Gravis Foundation Of America (MGFA) MG rating between class I and IV (class V indicating a crisis requiring intubation) while on optimized anticholinesterase therapy. Those who both do and do not undergo thymectomy, take oral prednisone, receive immunosuppressive therapy, or test positive for serum AChR antibodies will be included.
Exclusion criteria
Exclusion criteria: Exclusion criteria will include: thymoma on computed tomography or magnetic resonance imaging of the chest, pregnancy or lactation, contraindications for the use of corticosteroids, prednisone, or immunosuppressants, another previous or concurrent signi?cant disease (e.g., malignant tumor, serious cardiovascular disease, or lung disease).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Three-year mortality rates;Occurrence of myasthenic crisis;MGFA classification;The difference in optimal and total prednisone and immunosuppressant dose used over the 3-year trial period;Age at which surgery occurred among thymomatous MG patients; | — |
Countries
China
Contacts
Public ContactQilong Jiang
the First Affiliated Hospital, Guangzhou University of Chinese Medicine
Outcome results
None listed