chronic glomerulonephritis
Conditions
Interventions
Patients with chronic glomerulonephritis:Qi-tonifying formula
Normal control:none
Sponsors
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 35-70 years old, male or female; 2. TCM diagnosis of Qi-deficiency syndrome; 3. CGN diagnostic criteria, greater than 50% of participants having kidney biopsy; 4. urinary protein excretion between 0.5 and 6g/d; 5. eGFR =30 mL/min (calculated using the Chronic Kidney Disease Epidemiology Collaboration creatinine equation), serum albumin =30g/L; 6. Controlled hypertension, blood pressure < 140/90 mmHg; 7. Volunteers participate with signed the Letter of Informed and Consent.
Exclusion criteria
Exclusion criteria: 1. Patients with secondary renal diseases (e.g., lupus nephritis, Diabetic kidney disease, hypertensive kidney lesion); 2. Those who have complicated accompanying syndromes, including excess syndromes such as phlegm, coldness, and heat toxicity, as well as patients with obvious yin deficiency or yang deficiency; 3. Patients with major systemic diseases combined such as the cardio-cerebral-vascular system, nervous system, and immune system; 4. Patients who has taken glucocorticoids, immunosuppressants or antibiotics in the past 1 month; 5. Patients with allergic constitution; 6. Women who are pregnant, lactating, or have a pregnancy intention or positive pregnancy test (test urine HCG or blood HCG), or those who cannot take effective contraception during the study (effective contraception includes sterilization, IUD, oral contraceptives or the diaphragm method by the local law); 7. Patients who participated in other drug clinical trials in the past 1 month; 8. Patients with mental disorders, neurological impediments, or failure to express themselves or communicate; 9. Alcoholics, drug abusers and addicts.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| 24-hour urine protein;urinary red blood cell;serum creatinine;eGFR; | — |
Primary
| Measure | Time frame |
|---|---|
| The syndrome scorings of the Qi-deficiency; | — |
Countries
China
Contacts
Public ContactRenhuan Yu
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Outcome results
None listed