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Toleragenic mechanism of Langerhans cells mediated by Langerin-autophagy and its role in the pathogenesis of atopic dermatitis

Toleragenic mechanism of Langerhans cells mediated by Langerin-autophagy and its role in the pathogenesis of atopic dermatitis

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800017479
Enrollment
Unknown
Registered
2018-08-01
Start date
2018-08-31
Completion date
Unknown
Last updated
2018-08-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atopic dermatitis

Interventions

LewisY-BSA stimulation:LewisY-BSA
BSA control:BSA

Sponsors

Institute of Dermatology, Chinese Academy of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Umbilical cord blood was from healthy females age from 22 to 50, full-term pregnancy and spontaneous delivery. 2. Skin samples were normal tissues or foreskins removed after surgery from healthy controls age from 18 to 70. All were volunteered for this study and signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with severe systemic diseases that intefere with this study; 2. Lactating females; 3. Any other situations not suitable for this study determined by the investigators.

Design outcomes

Primary

MeasureTime frame
activation of Langerhans cells;T cells polarization;autophagy level of Langerhans cells;—

Countries

China

Contacts

Public ContactXu Yao

Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College

dryao_xu@126.com+86 13512513536

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026