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Effect and mechanism study of genetic variation on the dexmedetomidine metabolism and clinical effects

Effect and mechanism study of genetic variation on the dexmedetomidine metabolism and clinical effects

Status
Recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800017474
Enrollment
Unknown
Registered
2018-07-31
Start date
2018-08-01
Completion date
Unknown
Last updated
2018-08-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gynecologic surgery patients

Interventions

Sponsors

The Third Xiangya Hospital of Central South University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: (1) young people aged 18-45 years old; (2) the subjects must have informed consent before the trial and voluntarily sign the written informed consent; (3) subjects were able to communicate well with researchers and complete research in accordance with research requirements.

Exclusion criteria

Exclusion criteria: (1) abnormal liver and kidney function (AST, ALT above 2 times normal upper limit; Scr normal upper limit 1.2 times higher); (2) compensated circulatory disorder (severe hypotension), grade II-III atrioventricular block, severe cardiovascular disease, and endocrine system diseases; (3) taking alpha 2 agonist or antagonist (such as clonidine) within 14 days before operation, taking anticonvulsant or cardiovascular active drugs before operation; (4) any drug that inhibits or induces the metabolism of the liver during the first 30 days of the trial (such as the inducer - barbiturate, C Masi Bing, phenytoin, glucocorticoid, Omeprazole; inhibitors - SSRI antidepressants, cimetidine, diltiazem, macrocyclic ester, nitroimidazole, sedative hypnotics, and hypnotics) Vera Pammy, fluoroquinolones, antihistamine; (5) blood donation and blood donation >400mL or blood transfusion were taken within 3 months before the test; (6) drug abusers or the use of soft drugs (such as cannabis) within 3 months prior to the trial or a hard drug (such as cocaine, piperidine, etc.) within 1 years before the trial; (7) women in pregnancy or lactation; (8) subjects may not be able to complete the study or other researchers who think they should not be included for other reasons.

Design outcomes

Primary

MeasureTime frame
Sedation effect;

Countries

China

Contacts

Public ContactOuyang Wen

The Third Xiangya Hospital of Central South University

ouyangwen133@vip.sina.com+86 18975183003

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026