Obesity
Conditions
Interventions
Intensive intervention group:Physicians, nutritionists, and health managers jointly manage and direct the subjects online through the mobile application Medical Weight Management in real time
Self-monitoring group:Physicians, nutritionists, and health managers monthly provide the subjects weight loss programs and face-to-face guidance
the subjects do self-monitoring during the visit interphase
Sponsors
The First Affiliated Hospital, Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-50 years; 2. BMI=28.0kg/m2; 3. Agree to eat meals and exercise on time, monitor and record relevant indicators in accordance with the program requirements throughout the study; 4. Capable of using smartphones and operating the mobile application "Medical Weight Management".
Exclusion criteria
Exclusion criteria: 1. Patients with gastrointestinal diseases accompanied by malabsorption; 2. In the stage of active liver diseases, or with obvious liver function damage, wich is defined as alanine aminotransferase (ALT) > 2.5 times the normal upper limit; 3. A history of unstable or rapidly progressive renal disease or renal impairment, which is defined as serum creatinine = 133 mol/L (1.5mg/dl) in male subjects or = 125 mol/L (1.4mg/dl) in female subjects; 4. Diagnosed with diabetes, Obesity caused by Cushing syndrome and other endocrinology diseases; 5. Patients who have taken the following drugs within the last 4 weeks: hypoglycemic drugs, lipid-lowering drugs (such as statins, betts, etc.), diet drugs, liver protection drugs, glucocorticoids, and drugs that may affect blood glucose, blood lipids, pancreatic islet function and other indicators; 6. patients who have performed weight-reduction surgery; 7. Patients with mental disorders, unwillingness to communicate with others or language barrier, leading to insufficient understanding of the research program or incapability to cooperation with researchers; 8. Patients with severe cardiopulmonary insufficiency, hypothyroidism or malignant tumors; 9. Women who are pregnant, or who are planning to be pregnant during the study, or who have the ability to be pregnant but refuse to use effective, medically approved contraception during the study, or who are breastfeeding; 10. With a history of alcoholism, the amount of alcohol consumed by men = 140g per week, and that of women = 70g; 11. Physical dysfunction, affecting aerobic exercise and resistance exercise; 12. Those who are currently participating in other weight loss programmes or have lost more than 5 per cent of their body weight in the past six months; 13. Patients with poorly controlled severe hypertension, i.e., systolic blood pressure = 180mmHg and/or diastolic blood pressure = 110mmHg; Patients with systolic blood pressure <95mmHg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body Mass Index (BMI);body weight; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum Lipid;Index of glucose metabolism;Index of inflammation;human components;metabolic rate;liver fat content;measurements of neck, waist and hip;PCSK9;blood pressure;islet function;routine urine test; | — |
Countries
China
Contacts
Public ContactHongwen Zhou
The first Affiliated Hospital of Nanjing Medical University
Outcome results
None listed