anxious depression
Conditions
Interventions
Non-anxious depression:None
anxious depression 1:None
anxious depression 2:drug plus rTMS
anxious depression 3:drug plus sham coil rTMS
Sponsors
Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The relationship between resting state EEG asymmetry and abnormal attention (bias/generalization) 1.1. Inclusion criteria of patients (20 in each group): 1.1.1 Anxious depression patientsa. First-episode depression patient or patient who has not been treated with antidepressants for more than 3 monthsb. 18-55 years oldc. Ethnic: Hand. right-handednesse. Compliance with DSM- V diagnostic criteria for depressionf. Score of Wechsler Adult Intelligence Scale >= 70g. Hamilton Depression Scale (24 items) (HAMD)=17, and the score of Anxiety / somatization symptom dimension=7 h. Volunteer to participate in the study and sign informed consent; 1.1.2. Non-anxious depressiona-f. The same as a to f in part 1.1.1g. Hamilton Depression Scale (24 items) (HAMD)=17, and the score of Anxiety / somatization symptom dimension<7 h. The same as h in part 1.1.1. 1.2. Inclusion criteria of healthy volunteers a-d. The same as b to d and f in part 1.1.1e. normal social function, full capacity and responsibilityf. The same as h in part 1.1.1. 2. Effect of rTMS treatment on abnormal attention (bias/generalization) in anxious depression: 2.1. Inclusion criteria of anxious depression patients: Fully understand the safety and side effects of transcranial magnetic stimulation. The others are same as part 1.1.1. 2.2. Inclusion criteria of healthy volunteers Same as part 1.
Exclusion criteria
Exclusion criteria: 1. The relationship between resting state EEG asymmetry and abnormal attention (bias/generalization) 1.1. Exclusion criteria of patients: Has serious heart, liver or kidney etc. diseases, or women in pregnancy or lactation; Cerebral organic disease or nervous system disease; AIDS or history of syphilisd. History of long term alcohol intakee. comorbid with other DSM- V axis I, II diseases (such as Schizophrenia, obsessive-compulsive disorder or substance-related disorder, etc.); has been treated with rTMS or electroconvulsive therapy within 1 yearg; history of ocular trauma, history of ocular or extraocular muscle diseases, or myopia which higher than 400 degreesh; does not cooperate. 1.2 Exclusion criteria of healthy volunteers: History of past illness (Any DSM- V axis I, II diseases or history of brain injury); family historyhistory of mental illness in the familyc; history of treatment (has taken antipsychotic or antidepressant drugsOne month before taking part in the study, Benzodiazepine or other drugs that can affect the central nervous system were used Six months of continuous drug treatment); same as c, d, g in part 1.1. 2. Effect of rTMS treatment on abnormal attention (bias/generalization) in anxious depression: 2.1 Exclusion criteria of anxious depression patients: Same as part 1.1. 2.2 Exclusion criteria of healthy volunteers: The same as part 1.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| resting state EEG asymmetry index;N2pc;SPN;LPP;Hamilton Depression Scale (24 items);Hamilton anxiety scale (14 items); | — |
Countries
China
Contacts
Public ContactZhong Zheng; Tingting Yan
Sichuan University
Outcome results
None listed