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Comparison of sevoflurane and propofol on incidence of postoperative pain and quality of life in patients undergoing total knee arthroplasty with chronic pain before surgery

Comparison of sevoflurane and propofol on incidence of postoperative pain and quality of life in patients undergoing total knee arthroplasty with chronic pain before surgery

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1800017450
Enrollment
Unknown
Registered
2018-07-30
Start date
2018-08-06
Completion date
Unknown
Last updated
2019-12-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total knee arthroplasty

Interventions

P:Propofol
S:Sevoflurane

Sponsors

Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Aged>= 18 years; 2. Sign informed consent; 3. ASA class I to III; 4. Meet the indications of knee replacement surgery; 5. preoperative Visual Analogue Scale (VAS) > 4

Exclusion criteria

Exclusion criteria: 1. contraindications to a femoral-sciatic nerve block; 2. mental or language barrier; 3. regular opioid; 4. alcohol or drug abuse; 5. inadequate comprehension of the Chinese language or were diagnosed with a psychotic disorder; 6. any condition that the investigator determined would adversely affect the study.

Design outcomes

Primary

MeasureTime frame
Incidence of postoperative pain;—

Secondary

MeasureTime frame
Postoperative quality of life score(EQ-5D);Incidence of postoperative delirium;—

Countries

China

Contacts

Public ContactGuang-hong Xu

Department of anesthesiology, The First Affiliated Hospital of Anhui Medical University

xuguanghong2004@163.com+86 13856949535

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026