T-cell lymphoma
Conditions
Interventions
Experiement group:Neoantigen-activated haploidentical T cell therapy in the treatment group after failure of first-line treatment
Control group:Second line treatment
Sponsors
The Affiliated Zhuzhou Hospital Xiangya Medical College CSU
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. The pathological diagnosis is T-cell lymphoma; 2. Next-generation sequencing of the tumor cells shows multiple gene mutations; 3. After 2 courses of conventional first-line therapy, the patient is judged to be ineffective or progress; 4. There is donor for haploidentical T cell therapy; 5. There is no significant organ failure in patient and the estimate life is more than 60 days; 6. aged between 18 and 75 years.
Exclusion criteria
Exclusion criteria: 1. Next-generation sequencing of the tumor cells shows no multiple gene mutations; 2. Patient is initial diagnosis or the first-line treatment is effective for Patient; 3. No suitable donor for haploidentical T cell therapy; 4. There is significant organ failure in patient or the estimate life is less than 60 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ECOG score standard;time to progression;therapeutic effect evaluation;therapeutic effect evaluation;next generation sequencing of 197genes; | — |
Secondary
| Measure | Time frame |
|---|---|
| cytokines; | — |
Countries
China
Contacts
Public ContactGuoyu Hu
The Affiliated Zhuzhou Hospital Xiangya Medical College CSU
Outcome results
None listed