acute lymphoblastic leukemia
Conditions
Interventions
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-80 years; 2. Expected survival beyond 12 weeks; 3. Patients with acute lymphoblastic leukemia diagnosed by pathology and histology; 4. Patients have contraindications to chemotherapy or transplantation or refuse to undergo chemotherapy and hematopoietic stem cell transplantation; 5. Creatinine 50; 9. Patients without severe liver, kidney, heart disease; 10. Venous blood could be obtained or no contraindications for white blood collection; 11. Patients can understand and voluntarily sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients in pregnancy or breast-feeding period; Planning pregnancy within 6 months; 2. HIV or active TB infected or active hepatitis B or hepatitis C infection; 3. Feasibility assessment during screening demonstrates <10% transduction of target lymphocytes, or insufficient expansion (<5-fold) in response to CD3/CD28 costimulation; 4. Patients with abnormal vital signs or could not cooperate with inspectors; 5. History of mental disorders; 6. Highly allergic constitution or severe allergies, especially allergic to IL-2; 7. Systemic infection or serious infections should be local anti-infection treatment; 8. With heart, lung, brain, kidney and other important organ dysfunction; 9. Presence of severe autoimmune disease; 10. Other situations we think improper for the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete remission rate;Progression Free Survival;Overall Survival;Safety; | — |
Countries
China
Contacts
Public ContactKailin Xu
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed