rapid eye movement sleep behaviour disorder
Conditions
Interventions
treatment group with idebenone:idebenone 30mg po tid
control group with placebo :placebo 1pill po tid
Sponsors
Shaanxi Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: Polysomnography should be performed in RBD patients with associated clinical symptoms.The diagnostic criteria for RBD are in accordance with the the second edition of the International Classification of Sleep Disorders (ICSD-2) 6, which emphasizes the high sensitivity and specificity of polysomnography: 1. REM sleep without flaccid: electromyography shows that the amplitude of the submental electromyography is continuous or intermittent, or excessive occurrence of mental or limb myoelectric twitching during the excessive occurrence of mental or limb myoelectric convulsions; 2. Meet at least one of the following items: (1) with history of sleep related injury, potential injury or destructive action; (2) PSG monitoring video The abnormal behavior of the REM sleep period; (3) REM sleep period electroencephalogram (EEG) without epileptic activity, or can clearly distinguish between RBD and any other epilepsy in the same period of REM sleep; (4) its sleep disease can not be explained by other sleep diseases, internal medical or mental illness, and drug use.
Exclusion criteria
Exclusion criteria: (1) known severe vascular encephalopathy or normal pressure hydrocephalus on magnetic resonance imaging(MRI); (2) current or past treatment with antipsychotic drugs; (3) sleep disorder was induced by any other severe disease, such as severe anemia, hyperthyroidism, tumor and so on.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Index of rapid eye movement sleep;Index of rapid eye movement sleep; | — |
Countries
China
Contacts
Public ContactHou Chen
Shaanxi Provincial People's Hospital
Outcome results
None listed