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Efficacy and safety of oral ibuprofen versus paracetamol in preterm infants with patent ductus arteriosus:A retrospective evaluation study

Efficacy and safety of ibuprofen and acetaminophen in the treatment of patent ductus arteriosus in premature infants

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1800017389
Enrollment
Unknown
Registered
2018-07-27
Start date
2018-08-01
Completion date
Unknown
Last updated
2018-07-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patent ductus arteriosus

Interventions

paracetamol group:15mg/kg/ 6h/3d
high dose of ibuprofen group:10mg / kg /24h/3d
low dose of ibuprofen group:First day 10mg/kg, then 5 mg/kg for last two days

Sponsors

Children's Hospital of Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 1 Years

Inclusion criteria

Inclusion criteria: (1) admission within 24 hours after birth; (2) gestational age of 1.5mm) detected by echocardiography within 48 hours after birth.

Exclusion criteria

Exclusion criteria: (1) Congenital heart disease with PDA and patent foramen ovale; (2) subcutaneous hemorrhage or active bleeding before treatment; (3) the persistent pulmonary hypertension of the newborn; (4) suspected or confirmed necrotizing enterocolitis; (5) renal failure; (6) death cases that were not related to PDA.

Design outcomes

Primary

MeasureTime frame
patent ductus arteriosus closure rate;—

Countries

China

Contacts

Public ContactZhiping Li

Children's Hospital of Fudan University

zhipinglifudan@yeah.net+86 18017590744

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026