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The clinical application of extracellular histones in the treatment of ARDS by ECMO with the new lung ventilation strategies guided by transpulmonary pressure

The clinical application of extracellular histones in the treatment of ARDS by ECMO with the new lung ventilation strategies guided by transpulmonary pressure

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1800017384
Enrollment
Unknown
Registered
2018-07-27
Start date
2018-10-01
Completion date
Unknown
Last updated
2018-07-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory distress syndrome

Interventions

New ventilation strategy group vs traditional ventilation strategy group:the choice of ventilation strategy

Sponsors

Shanghai Pulmonary Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
19 Years to 64 Years

Inclusion criteria

Inclusion criteria: 1. Pathogeny reversible ARDS; 2. Oxygenation index(PaO2/FiO2)600mmHg; 4. Murray lung injury score=3.0; 5. Blood gas analysis pH<7.2; 6. Aged 18 to 65 years.

Exclusion criteria

Exclusion criteria: 1. Airway pressure>30cmH2O; 2. Inspired oxygen concentration>80%; 3. Duration of mechanical ventilation>7 days; 4. Intracranial hemorrhage; 5. Contraindications to the use of heparin; 6. History of esophagus surgery or injury.

Design outcomes

Primary

MeasureTime frame
parameters of pulmonary mechanics;hemodynamics parameters;Oxygen dynamics parameters;extracellular histones;Inflammatory cytokines;—

Countries

China

Contacts

Public ContactWen Zongmei

Shanghai Pulmonary Hospital

wzm1103@126.com+86 13761635280

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026