Rosacea
Conditions
Interventions
rapamycin treated group:topical application of rapamycin cream
Substrate:topical application of substrate cream
Sponsors
Xiangya Hospital Central South University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Patients were eligible if they were aged = 18 years; 2. had a clinical diagnosis of papulopustular rosacea assessed by one of the dermatologists; had a score > 1; 3. Investigators Global Assessment (IGA); 4. had at least eight inflammatory lesions (papules and/or pustules) and had a score > 1 on Clinicians Erythema Assessment (CEA); 5. Female patients were required to have a recent negative urine pregnancy test, and should have used a form of contraceptive.
Exclusion criteria
Exclusion criteria: 1. pregnant, nursing or planning pregnancy; 2. initiated or changed a hormonal method of contraception within 3 months prior to baseline; 3. had a dermatosis that might interfere with rosacea or the evaluation of treatment results; 4. had known hypersensitivity to tetracyclines; 5. had used topical therapy within 2 weeks prior to baseline; 6. had used systemic or laser therapy for rosacea within 4 weeks prior to baseline; had used any investigational drug within 4 weeks; 7. had used isotretinoin in the 6 months prior to baseline; had known or suspected achlorhydria or had surgery to bypass or remove the duodenum; 8. known or suspected to have hepatic impairment or were receiving potentially hepatotoxic medicinal products; 9. had current drug or alcohol abuse; 10. to be considered to unsuitable to participate in this trial by their treating physicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| facial erythema, telangiectasia, papules, pustules, edema; | — |
Countries
China
Contacts
Public ContactJi Li
Central South University Xiangya Hospital
Outcome results
None listed