advanced malignant solid tumors
Conditions
Sponsors
The First Hospital Affiliated to AMU/Southwest Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Patients with recurrent/metastatic advanced gastric cancer, colon cancer, liver cancer, lung cancer, ovarian cancer, cervical cancer, breast cancer, osteosarcoma, soft tissue sarcoma or other refractory solid tumors diagnosed by histology or cytology; 2. Aged 18 years old or above, male or female; 3. ECOG PS: 0-3 points; 4. The expected survival period is greater than or equal to 12 weeks; 5. The main organ function levels meet the following criteria: The main organs function normally, that is, the following criteria are met: (1) Blood routine examination standards should be consistent with: ANC=1.5×10^9/L, PLT=75×10^9/L, Hb=90g/L (no blood transfusion and blood products within 14 days, no correction by G-CSF and other hematopoietic stimuli); (2) Biochemical examination should meet the following criteria: TBIL<1.5×ULN, ALT, AST<2.5×ULN patients with liver metastasis can <5×ULN, BUN and Cr=1×ULN or endogenous creatinine clearance =50ml/min (Cockcroft-Gault formula); 6. Women of childbearing age should be carried out in the group of 7 days before the pregnancy test (serum or urine), and the results were negative, and willing to during the test and the last to test drugs after 8 weeks, using appropriate methods of contraception; 7. Subjects voluntarily participated in this study, signed informed consent, followed up with good compliance.
Exclusion criteria
Exclusion criteria: 1. Symptomatic brain metastasis, cancerous meningitis (patients with brain metastasis who have completed treatment and stable symptoms for 21 days before enrollment,those patients can be enrolled, but need to be confirmed by brain MRI, CT or venography to have no cerebral hemorrhage symptoms); 2. People with high blood pressure who cannot be reduced to the normal range by antihypertensive medication (systolic blood pressure >140 mmHg, diastolic blood pressure >90 mmHg); 3. myocardial ischemia with above grade II or myocardial infarction, arrhythmia 4. Have a bleeding tendency or are receiving thrombolytic or anticoagulant therapy; 5. Major surgery or severe traumatic injury, fracture or ulcer within 4 weeks of enrollment; 6. A variety of factors affecting oral medications (such as inability to swallow, chronic diarrhea and intestinal obstruction, significantly affecting the use and absorption of drugs); 7. Abdominal fistula, gastrointestinal perforation or abdominal abscess occurred within 6 months before enrollment; 8. Urine routinely showed urinary protein = ++ or confirmed 24-hour urine protein quantitation > 1.0 g; 9. Patients with a history of psychotropic substance abuse who cannot be cured or who have mental disorders; 10. Pregnant or lactating women; those who have fertility are unwilling or unable to take effective contraceptive measures; 11. The investigator determines other conditions that may affect the conduct of the clinical study and the outcome of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| progression-free survival ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival; | — |
Countries
China
Contacts
Public ContactXuequan Huang
The First Hospital Affiliated to AMU/Southwest Hospital
Outcome results
None listed