Major depressive disorder
Conditions
Interventions
Sponsors
The First Affliated Hospital Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1) met the Diagnostic and Statistical Manual of Mental Disorders, IV Edition (DSM-IV) criteria for current unipolar MDD episode, without psychiatric symptoms; 2) first episode or recurrent depression, without treatment; 3) 17-HAMD=17; 4) the Han ethnicity, right hand; 5) at least junior middle school level of education; 6) aged 18–45 years.
Exclusion criteria
Exclusion criteria: 1. treated with antidepressant or antipsychotics, or rTMS, or ECT, or others; 2. with any other psychiatric disorder, or with a family history of psychiatric disorders (first degree relative); 3. mental disorders due to organic disease or drugs; 4. with neurological disease (stroke or epilepsy), physical disease (heart disease or liver disease), with endocrinic disease(hypertension or diabetes; 5. with alcohol or drug abuse 6. with suicidal idea or behavior,irritability or excitement behavior etc.; 7. contraindications to MRI scan, including metallic implants, retractors or braces, and claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Orexin-A;Orexin-B;Vasopressin;Melatonin;5-HT;IL;ifna;tnfa;molecular on T cells;MRI data;psychological index; | — |
Countries
China
Contacts
Public ContactXu Yi
The First Affliated Hospital Zhejiang University School of Medicine
Outcome results
None listed