recurrent priapism
Conditions
Interventions
Ethylphenylephrine intervention group:Receiving 30mg of ephedrine per day
Sildenafil intervention group:Recenving sildenafil 50mg once daily
Control group:Only deals with acute attacks that last more than 4 hours
Sponsors
Xiangya Hospital of Centre South University
Eligibility
Sex/Gender
Male
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: Patients with sickle cell disease (diagnosed as SS or SC hemoglobin disease), aged 20 to 45 years, were recruited from the emergency department, department of hematology and department of urology clinic in our hospital. There are at least 2 obvious penile erection episodes per week, and they have independent behavioral capacity and can sign written informed consent.
Exclusion criteria
Exclusion criteria: Glomerular filtration rate less than 50 mL/min, clinical cirrhosis, pulmonary hypertension, hypertension, coronary heart disease, or other contraindication of phosphodiesterase 5 inhibitors and alpha receptor agonist
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of priapism episodes biweekly from the baseline; | — |
Secondary
| Measure | Time frame |
|---|---|
| The average duration of an abnormally erection documented biweekly;The times of hospitalizations due to persistent erection; | — |
Countries
China
Contacts
Public ContactZheng-Yan Tang
Xiangya Hospital of Central South University
Outcome results
None listed