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Study on epigenetic mechanism of Chronic Hepatitis B syndrome differentiation based on DNA methylation

Study on epigenetic mechanism of Chronic Hepatitis B syndrome differentiation based on DNA methylation

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800017365
Enrollment
Unknown
Registered
2018-07-26
Start date
2018-07-20
Completion date
Unknown
Last updated
2018-07-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Hepatitis B

Interventions

Sponsors

Chengdu University of TCM
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. It conforms the diagnostic criteria of Chronic Hepatitis B and TCM syndrome differentiation criteria at the same time; 2. Aged between 18 and 60 years; 3. Agree and sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Concomitant with other types of hepatitis virus or/and HIV infection; 2. Patients with cirrhosis or malignant tumors; 3. Concomitant drug or toxic liver injury, autoimmune hepatitis, hereditary - metabolic liver disease; 4. Unclear consciousness, unable to express subjective symptoms of discomfort and psychotic patients; 5. Those with serious diseases such as heart, lung, kidney, endocrine and blood; 6. The researchers found that other conditions were not suitable for participation in the study.

Design outcomes

Primary

MeasureTime frame
DNA methyltransferase;methylated chip;Methylated DNA binds to the protein MeCP2;The target gene of mir-122 is cyclin G1;

Countries

China

Contacts

Public ContactZheng Xiuli

Chengdu University of TCM

zhengxiuli023@163.com+86 18081062358

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 23, 2026