acute ST-segment elevation myocardial infarction
Conditions
Interventions
Study group:Biantong capsule
Control group:Biantong capsule mimetic agent
Sponsors
Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age >18 years male and female; 2. Conform to the criteria for the diagnosis of acute ST segment elevation myocardial infarction: myocardial ischemia symptoms for 30 minutes or more, electrocardiogram shows at least two leads of ST-elevation > 0.05 mv in the adjacent two chest lead or > 0.1 mv in the body leads, or new left bundle branch block; 3. The time from onset to admission is less than 3 days; 4. Voluntarily sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Constipation with dry feces and laborious defecation at least 6 months before admission; 2. Patients with diarrhea within 7 days of admission; 3. Patients who have used drugs to treat constipation for nearly 2 weeks; 4. Patients with known organic lesions of the colon and rectum and chronic functional intestinal diseases; 5. Patients with known severe cerebrovascular disease or other neuropsychiatric disorders, leading to a lack or loss of autonomic bowel control; 6. Patients with known severe liver dysfunction (ALT or AST levels more than 3 times higher than the upper limit of normal values), renal insufficiency (GFR<30ml/min), moderate to severe chronic obstructive pulmonary disease, and pulmonary hypertension; 7. Women known or preparing for pregnancy or lactation; 8. People who are known to be allergic or have severe adverse reactions to the capsule and its contents; 9. Have participated in other clinical studies within 3 months prior to the study or are currently participating in other clinical researchers; 10. According to the judgment of the researcher, patients who cannot complete the study or who cannot comply with the requirements of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complex cardiovascular endpoint events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Area under the curve(AUC) of myocardial oxygen consumption;Area under the curve(AUC) of average value of the change in ST segment;Cardiovascular death + recurrent nonfatal myocardial infarction;All-cause death; | — |
Countries
China
Contacts
Public ContactShaoping Nie
Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University
Outcome results
None listed