acute lung injury
Conditions
Interventions
Control group:no mechanical ventilation during CPB
Experimental group:Continuing low-volum ventilation during CPB
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) Patients who received cardiac valve replacement; (2) Valve disease without other cardiac malformations or macrovascular lesions; (3) Age>18 years; (4) sinus rhythm
Exclusion criteria
Exclusion criteria: (1) Reoperation; (2) Preoperative mechanical ventilation' (3) Acute arotic dissection with valve diseases; (4) Preoperative liver dysfunction or chronic kidney diseases; (5) Quit smoking time shorter than three months; (6) Preoperative severe thoracic deformity; (7) Preoperative other cardic diseases, immune system diseases or musculoskeletal diseases; (8) History of tumor diseases; (9) History of allergic to anaesthetic; (10) History of malignant hyperthermia; (11) History of alcohol or sedative dependence; (12) Preoperative Coagulation disorders; (13) Preoperative infective endocarditis; (14) Congenital heart diseases; (15) Coronary artery diseases; (16) Myasthenia gravis; (17) Thrombocytopenia; (18) Preoperative pulmonary dysfunction or COPD; (19) PaO245mmHg; (20) Unwilling to join in this research; (21) Have been included in other programmes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interleukin-6;Interleukin-8;Interleukin-10;Krebs von den lungen-6;PaO2/FiO2;PA-aO2; | — |
Countries
China
Contacts
Public ContactJia Hu
West China Hospital, Sichuan University
Outcome results
None listed