Knee Articular Cartilage Degeneration and Damage
Conditions
Interventions
Experimental:HTO therapy combine with AD-MSCs + sodium hyaluronate
Control:HTO therapy combine with sodium hyaluronate
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Aged 18-65 years, male and female, patient can tolerate surgery; 2) Clinical diagnosis of degenerative arthritis by Radiographic Criteria; 3) Obviously extra-articular malformation; 4) Good contralateral interventricular cartilage; 5) Course of disease = six months; 6) There was no obvious abnormality in tumor marker detection,or patient was evaluated has not at the risk of cancer; 7) Subjects who understand and sign the consent form for this study.
Exclusion criteria
Exclusion criteria: 1) Acute joint injury; 2) Patients with severe primary diseases, such as cardiovascular, cerebrovascular, liver, kidney and hematopoietic system, and psychosis; 3) Cancer patients; 4) Women who are pregnant or breast feeding,or allergic constitution patient; 5) Positive serology for HIV-1 or HIV-2, Hepatitis B (HBsAg, Anti-HCV-Ab), Hepatitis C (Anti-HCV-Ab) and syphilis; 6) Receive other open surgery related to knee operation within 6 months; 7) Participation in another clinical trial; 8) Failing to comply with the inclusion criteria, unwilling to comply with the research approach, or incomplete data affecting the curative effect or safety judgment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Knee cartilage volume; | — |
Secondary
| Measure | Time frame |
|---|---|
| Osteoarthritis score;Visual Analogue Scale;Quality of life;Gait analysis; | — |
Countries
China
Contacts
Public ContactPeilai Liu
Qilu Hospital of Shandong University
Outcome results
None listed