hemophagocytic lymphohistiocytosis
Conditions
Interventions
Case series:CCHG-HLH-2018 regimen
Sponsors
Beijing Children's Hospital Medical, Capital Medical University, National Center for Children's Health
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1) Newly diagnosed HLH patients who met HLH-2004 diagnostic criteria; 2) Under the age of 18 years; 3) Informed consent was obtained.
Exclusion criteria
Exclusion criteria: If patients have one of the following conditions, they cannot be enrolled in this research: 1) Definite diagnosis of HLH associated with malignancies, autoimmune diseases and parasitic infections; 2) Allergic to drugs involved in the protocol; 3) Participate in other clinical studies at the same time; 4) Do not accept the full courses of this protocol; 5) Who has been diagnosed as HLH and has used VP16 in other hospitals.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| White blood cells;neutrophil;thrombocyte;hemoglobin;triglyceride;glutamic-pyruvic transaminase;glutamate transaminase;lactate dehydrogenase;sCD25;ferritin;NK activity;Fibrinogen;Total bilirubin;cytokines;Hemophagocytosis;EBV DNA;Cerebrospinal fluid;Abdominal ultrasound;head MRI; | — |
Secondary
| Measure | Time frame |
|---|---|
| myelosuppression;Infection;Bleeding;pancreatitis;Heart dysfunction; | — |
Countries
China
Contacts
Public ContactTian-You Wang
Beijing Children's Hospital Medical, Capital Medical University, National Center for Children’s Health, China
Outcome results
None listed