Gastric cancer
Conditions
Interventions
study group:oral apatinib
study group:paclitaxel intravenous
Sponsors
First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. advanced gastric cancer or gastroesophageal junction adenocarcinoma confirmed by histopathology and/or cytology; 2. malignant ascites (positive cytology of ascites); 3. recurrent and metastatic lesions, previously received at least first-line chemotherapy; 4. Aged 18 to 75 years old; 5. ECOG 0 to 2 points; 6. Estimated survival time = 3 months; 7. Blood tests meet the following requirements: WBC = 3×10^9/L, ANC = 1.5×10^9/L, Hb=80g/L, PLT=80×10^9/L; TBIL=1.5×ULN (upper limit of normal value), ALT and AST=2×ULN (if there is liver metastasis, =5×ULN; Endogenous creatinine clearance Rate = 60 ml/min (Cockcroft-Gault formula).
Exclusion criteria
Exclusion criteria: 1. Previously used for recurrence and metastatic foci; use of taxanes or anti-angiogenic drugs; 2. gastrointestinal bleeding or active hemorrhage in other areas or patients with risk of bleeding; 3. abnormal coagulation; 4. occurred within one year before screening Arterial/venous thromboembolic events; 5. active infections (including intra-abdominal infections); 6. uncontrolled diarrhea; and 7. patients with hypertension who cannot be reduced to normal range by antihypertensive drugs (systolic blood pressure >140 mmHg/diastolic pressure) > 90 mmHg; 8. suffering from coronary heart disease, arrhythmia and cardiac insufficiency = II; 9. chronic kidney disease; 10. pregnant or lactating women, and men and women who are unwilling to adopt contraceptive measures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| paracentesis-free interval; | — |
Secondary
| Measure | Time frame |
|---|---|
| progression-free survival;overall survival;overall survival;quality of life score; | — |
Countries
China
Contacts
Public ContactMa Tai
First Affiliated Hospital of Anhui Medical University
Outcome results
None listed