coronary heart disease
Conditions
Interventions
1:Bidobacterium Lactics M8
2:Placebo
Sponsors
Weihai Municipal Hospital, Shandong
Eligibility
Sex/Gender
All
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patient with coronary heart disease (version 2016 diagnostic criteria); 2. Aged between 35 and 75 years; 3. Good compliance for per protocol; 4. Agree to sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Pregnant or breast-feeding women; 2. Female patients of childbearing without any contraceptive measures; 3. Those who is known or suspected to allergy on the probiotics; 4. History of gastrointestinal disorder or surgery; 5. Use of antibiotics and immunosuppressant agents in the proceeding 4 weeks or the processing; 6. Ingestion of other probiotics or other probiotis; 7. Unstable life sign and unstable pantients. 8. Acute ST segment elevate myocardial infarction ,with serious arrhythmia or shock; 9. Patients with irregular eating habits and large changes of eating habits in following-up period; 10. The patients received other clinical trials at the same time; 11. Relay on controlled drugs and alcohol; 12. Refuse to sign informed consent; 13. Patients with insufficiency of liver and kidney; 14. Patients can not persist to the terminal point of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DNA of gut microbiome;Ttimethylamine N-oxide; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lnterkeukin-6;martix metalloprotease-9;short chain fat acid; | — |
Countries
China
Contacts
Public ContactXinfu Zhou
Weihai Municipal Hospital, Shandong
Outcome results
None listed