aciesis
Conditions
Interventions
Control group:Gn RH-a/r-FSH/HMG/HCG
Conventional acupuncture group:Gn RH-a/r-FSH/HMG/HCG and Conventional acupuncture
stage by stage acupuncture and moxibustion therapy:Gn RH-a/r-FSH/HMG/HCG and stage by stage acupuncture and moxibustion therapy
Sponsors
Yunnan University of TCM
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. patient and his or her spouse are aged 24 to 45 years old; 2. patients with regular menstrual cycle (27 ~ 35 days), and normal ovulation in the natural cycle; 3. basic endocrine is normal, the base FSH<10miu/ml, the serum bFSH=15mIU/ml on the 2nd to 5th day of menstruation, the number of ovarian follicles on the bilateral ovary is =6; 4. embryo transfer 3 times or more without pregnancy; 5. In the past 3 months, there was no history of hormonal use and history of uterine operation, and the uterine cavity was normal; At least 2 high quality embryos are portable during the 6IVF-ET cycle. 7. patients were patients with repeated IVF-ET transplantation requiring retransplantation; 8. patients have self-knowledge and signed informed consent, agreed to accept the study treatment plan, obey the research arranger.
Exclusion criteria
Exclusion criteria: 1. The uterus does not have the ability to give birth or serious physical illnesses, unable to bear pregnancy, suffering from serious mental illness, genitourinary infection, sexual disease, history of drug abuse, etc., which are extremely harmful to the health of the body, and exposure to a sufficient amount of teratogenic rays. The poison is still causing the onset of the disease; 2. chromosomal abnormalities; 3. endometriosis, uterine fibroids, tuberculosis, intrauterine adhesions and endometrial lesions; 4. polycystic ovary syndrome, ovarian cysts, hydrosalpinx and so on; 5. unconscious, unable to express subjective symptoms, accompanied by severe depression, anxiety or mental illness; 6. allergic or allergic to acupuncture; 7. progressive malignant tumors or other serious wasting diseases, easy to concomitant infection and bleeding; combined with cardiovascular, liver, kidney, digestion, hematopoietic system and other primary diseases can not afford pregnancy; 8. poor compliance, refusal to participate in the trial or reluctance to sign informed consent and difficulty in follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VEGF;VEGFmRNA;Endometrial volume;Endometrial blood flow classification;Endometrial three-dimensional volume blood flow;AMH;FSH;LH;E2;number of sinus follicle;D-dipolymer;Antithrombin III;Activation of partial thrombin activation time;homocysteine;HCG;Ultrasound B examination; | — |
Secondary
| Measure | Time frame |
|---|---|
| Health survey summary; | — |
Countries
China
Contacts
Public ContactZhao Rong
Yunnan University of TCM
Outcome results
None listed